imprint:
Proceedings of the National Academy of Sciences, 2016
Published in:
Proceedings of the National Academy of Sciences, 113 (2016) 48, Seite 13821-13826
Language:
English
DOI:
10.1073/pnas.1616574113
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
<jats:title>Significance</jats:title>
<jats:p>Epstein–Barr Virus infects human B cells and drives them into proliferation and transformation. Although more than 90% of the human population is EBV-infected, EBV-driven pathologies including B-cell lymphomas are limited by a potent T-cell immune response. Here, we present a mouse model for acute EBV infection through conditional expression of two key EBV proteins, LMP1 and LMP2A. This model reproduces EBV-driven B-cell expansion, T-cell–mediated immune surveillance of EBV-infected B cells, and fatal lymphoproliferative disease when the T-cell response is compromised as in immunosuppressed or genetically impaired patients. It thus allows one to study EBV–host interaction functionally and from an angle that should help to develop new therapies for EBV-driven hematological diseases.</jats:p>