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Media type:
E-Article
Title:
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
Contributor:
Zeltina, Antra;
Krumm, Stefanie A.;
Sahin, Mehmet;
Struwe, Weston B.;
Harlos, Karl;
Nunberg, Jack H.;
Crispin, Max;
Pinschewer, Daniel D.;
Doores, Katie J.;
Bowden, Thomas A.
Published:
Proceedings of the National Academy of Sciences, 2017
Published in:
Proceedings of the National Academy of Sciences, 114 (2017) 27, Seite 7031-7036
Language:
English
DOI:
10.1073/pnas.1702127114
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
Significance An estimated 5 million people are at risk of infection by Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever. JUNV displays a glycoprotein spike complex on the surface of the viral envelope that is responsible for negotiating host-cell recognition and entry. Herein, we show that monoclonal antibodies that have gone through different germline selection pathways have converged to target the host-cell receptor-binding site on the JUNV glycoprotein spike. Immunofocusing of the antibody response to mimic natural host–receptor interactions reveals a key point of vulnerability on the JUNV surface.