Contributor:
Bulgari, Dinara;
Jha, Anupma;
Deitcher, David L.;
Levitan, Edwin S.
Published:
Proceedings of the National Academy of Sciences, 2018
Published in:
Proceedings of the National Academy of Sciences, 115 (2018) 7, Seite 1617-1622
Language:
English
DOI:
10.1073/pnas.1716801115
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
SignificanceNeurotransmission relies on exocytosis of two vesicle types: small synaptic vesicles (SSVs) that contain small-molecule transmitters and dense-core vesicles (DCVs) that contain neuropeptides. The secretory apparatus for synaptic exocytosis has appeared to be conserved for the two vesicle types. This study at the fruit fly neuromuscular junction shows that up- or down-regulating the multifunctional protein Myopic increases synaptic neuropeptide stores by selectively reducing synaptic neuropeptide release evoked by electrical activity or cAMP. In contrast, SSV-mediated release is not affected by Myopic. These results show that Myopic, which is already implicated in neuropeptide gene expression, selectively participates in exocytosis of synaptic DCVs.