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Media type:
E-Article
Title:
Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke
Contributor:
Liang, Huixuan;
Zhao, Handi;
Gleichman, Amy;
Machnicki, Michal;
Telang, Sagar;
Tang, Sydney;
Rshtouni, Mary;
Ruddell, Jack;
Carmichael, S. Thomas
Published:
Proceedings of the National Academy of Sciences, 2019
Published in:
Proceedings of the National Academy of Sciences, 116 (2019) 27, Seite 13621-13630
Language:
English
DOI:
10.1073/pnas.1811825116
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
Significance Recovery after stroke involves remodeling in brain tissue adjacent to the stroke site. In this remodeling, neurogenesis after stroke involves the formation of new neurons. The role of neurogenesis in stroke recovery and the role of brain and behavioral activity in this process remain undefined. Using orthogonal transgenic mouse tracing and rabies virus approaches, we demonstrate that brain regions unexpectedly compete for new neurons after stroke and that the behavioral or cellular activity establishes this competition. These new neurons synaptically integrate into cortex, and this integration is necessary for poststroke recovery.