A unique covalent bond in basement membrane is a primordial innovation for tissue evolution

Media type: E-Article
Title: A unique covalent bond in basement membrane is a primordial innovation for tissue evolution
Contributor: Fidler, Aaron L.; Vanacore, Roberto M.; Chetyrkin, Sergei V.; Pedchenko, Vadim K.; Bhave, Gautam; Yin, Viravuth P.; Stothers, Cody L.; Rose, Kristie Lindsey; McDonald, W. Hayes; Clark, Travis A.; Borza, Dorin-Bogdan; Steele, Robert E.; Ivy, Michael T.; Hudson, Julie K.; Hudson, Billy G.
Published: Proceedings of the National Academy of Sciences, 2014
Published in: Proceedings of the National Academy of Sciences, 111 (2014) 1, Seite 331-336
Language: English
DOI: 10.1073/pnas.1318499111
ISSN: 0027-8424; 1091-6490
Origination:
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Description: Significance The evolution of multicellular animals from single-celled ancestors was one of the most significant transitions of life on earth. The emergence of larger, more complex animals able to resist predation and colonize new environments was enabled, in part, by a collagen scaffold, which anchors cells together to form tissues and organs. Here, we show that a unique chemical bond, a link between sulfur and nitrogen atoms called a sulfilimine bond, arose over 500 Mya, binding this scaffold together and enabling tissues to withstand mechanical forces. Peroxidasin forms the bond by generating hypohalous acids as strong oxidants, a form of bleach, which normally function as antimicrobial agents. These understandings may lead to approaches for targeting tumors and treatment of other diseases.
Access State: Open Access

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