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Xiao, Yiren; Thakkar, Kaushik N.; Zhao, Hongjuan; Broughton, James; Li, Yang; Seoane, Jose A.; Diep, Anh N.; Metzner, Thomas J.; von Eyben, Rie; Dill, David L.; Brooks, James D.; Curtis, Christina; Leppert, John T.; Ye, Jiangbin; Peehl, Donna M.; Giaccia, Amato J.; Sinha, Subarna; Rankin, Erinn B.

The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor

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  • Media type: E-Article
  • Title: The m 6 A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor
  • Contributor: Xiao, Yiren; Thakkar, Kaushik N.; Zhao, Hongjuan; Broughton, James; Li, Yang; Seoane, Jose A.; Diep, Anh N.; Metzner, Thomas J.; von Eyben, Rie; Dill, David L.; Brooks, James D.; Curtis, Christina; Leppert, John T.; Ye, Jiangbin; Peehl, Donna M.; Giaccia, Amato J.; Sinha, Subarna; Rankin, Erinn B.
  • Published: Proceedings of the National Academy of Sciences, 2020
  • Published in: Proceedings of the National Academy of Sciences, 117 (2020) 35, Seite 21441-21449
  • Language: English
  • DOI: 10.1073/pnas.2000516117
  • ISSN: 0027-8424; 1091-6490
  • Origination:
  • Footnote:
  • Description: <jats:title>Significance</jats:title> <jats:p>Here we report a synthetic lethal interaction between the epitranscriptomic modifier FTO and the tumor suppressor VHL. Notably, FTO inhibition reduced the growth of both HIF wild type and HIF-deficient tumors. These findings reveal an epitranscriptomic vulnerability of VHL-deficient cells and identify a potential HIF-independent therapeutic target for ccRCC tumors.</jats:p>
  • Access State: Open Access