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Ying, Lisha; Du, Lingbin; Zou, Ruiyang; Shi, Lei; Zhang, Nan; Jin, Jiaoyue; Xu, Chenyang; Zhang, Fanrong; Zhu, Chen; Wu, Junzhou; Chen, Kaiyan; Huang, Minran; Wu, Yingxue; Zhang, Yimin; Zheng, Weihui; Pan, Xiaodan; Chen, Baofu; Lin, Aifen; Tam, John Kit Chung; van Dam, Rob Martinus; Lai, David Tien Min; Chia, Kee Seng; Zhou, Lihan; Too, Heng-Phon; [...]

Development of a serum miRNA panel for detection of early stage non-small cell lung cancer

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  • Media type: E-Article
  • Title: Development of a serum miRNA panel for detection of early stage non-small cell lung cancer
  • Contributor: Ying, Lisha; Du, Lingbin; Zou, Ruiyang; Shi, Lei; Zhang, Nan; Jin, Jiaoyue; Xu, Chenyang; Zhang, Fanrong; Zhu, Chen; Wu, Junzhou; Chen, Kaiyan; Huang, Minran; Wu, Yingxue; Zhang, Yimin; Zheng, Weihui; Pan, Xiaodan; Chen, Baofu; Lin, Aifen; Tam, John Kit Chung; van Dam, Rob Martinus; Lai, David Tien Min; Chia, Kee Seng; Zhou, Lihan; Too, Heng-Phon; [...]
  • imprint: Proceedings of the National Academy of Sciences, 2020
  • Published in: Proceedings of the National Academy of Sciences
  • Language: English
  • DOI: 10.1073/pnas.2006212117
  • ISSN: 1091-6490; 0027-8424
  • Origination:
  • Footnote:
  • Description: <jats:title>Significance</jats:title> <jats:p>Lung cancer is the most prevalent and deadly cancer worldwide. Minimally invasive testing for early detection of lung cancer is the key for improving prognosis. In this study, we carried out a multicenter, multiethnic study to compare the serum miRNA profiles between 744 NSCLC and 944 healthy controls. We discovered 35 candidate miRNA biomarkers, verified 22 of them, and a panel of 5 miRNAs was optimized for detection of early stage NSCLC with AUC &gt; 0.90 in three independent validation cohorts. The sensitivity and specificity of five-miR panel for detection of stage I NSCLC were 83.0% and 90.7%, respectively. Our study will help to accurately detect early stage NSCLC through minimally invasive testing in the clinic.</jats:p>
  • Access State: Open Access