Description:
<jats:title>Significance</jats:title><jats:p>Aneuploidy, or an imbalanced chromosome content, is a hallmark of cancer. Paradoxically, aneuploidy is associated both with poor prognosis in cancer and with slow growth in primary cells. Here, we bridge these two seemingly contradictory observations: the cell cycle defects caused by aneuploidy protect cancer cells from chemotherapeutic damage. Our study may inform treatment decisions by impacting our understanding of how sensitive a particular tumor may be to certain chemotherapies.</jats:p>