Primate phageomes are structured by superhost phylogeny and environment

Media type: E-Article
Title: Primate phageomes are structured by superhost phylogeny and environment
Contributor: Gogarten, Jan F.; Rühlemann, Malte; Archie, Elizabeth; Tung, Jenny; Akoua-Koffi, Chantal; Bang, Corinna; Deschner, Tobias; Muyembe-Tamfun, Jean-Jacques; Robbins, Martha M.; Schubert, Grit; Surbeck, Martin; Wittig, Roman M.; Zuberbühler, Klaus; Baines, John F.; Franke, Andre; Leendertz, Fabian H.; Calvignac-Spencer, Sébastien
imprint: Proceedings of the National Academy of Sciences, 2021
Published in: Proceedings of the National Academy of Sciences
Language: English
DOI: 10.1073/pnas.2013535118
ISSN: 0027-8424; 1091-6490
Origination:
Footnote:
Description: <jats:title>Significance</jats:title> <jats:p>Mammals harbor diverse communities of gut microbes. The assembly and evolution of the bacterial components of these communities are influenced by host evolutionary histories and social behavior. Little is known about the ecological and evolutionary origins of the phages infecting these bacteria. We explore drivers of phage community assembly and phage lineage evolution in primates. Many phages codiverged with their superhosts. Furthermore, neighboring social groups harbor compositionally and evolutionary distinct phageomes, structured by superhost social behavior. Captive primate phageome composition is intermediate to humans and their wild primate counterparts, with phage phylogenies revealing replacement of wild-associated phages by human-associated lineages. This plasticity makes the long-term associations of phages with their superhosts observed across ecosystems and continents all the more striking.</jats:p>
Access State: Open Access

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