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Media type:
E-Article
Title:
A highly immunogenic and effective measles virus-based Th1-biased COVID-19 vaccine
Contributor:
Hörner, Cindy;
Schürmann, Christoph;
Auste, Arne;
Ebenig, Aileen;
Muraleedharan, Samada;
Dinnon, Kenneth H.;
Scholz, Tatjana;
Herrmann, Maike;
Schnierle, Barbara S.;
Baric, Ralph S.;
Mühlebach, Michael D.
Published:
Proceedings of the National Academy of Sciences, 2020
Published in:
Proceedings of the National Academy of Sciences, 117 (2020) 51, Seite 32657-32666
Language:
English
DOI:
10.1073/pnas.2014468117
ISSN:
0027-8424;
1091-6490
Origination:
Footnote:
Description:
<jats:title>Significance</jats:title>
<jats:p>The COVID-19 pandemic has already caused over 1 million deaths. Therefore, effective vaccine concepts are urgently needed. In search of such a concept, we have analyzed a measles virus-based vaccine candidate targeting SARS-CoV-2. Using this well-known, safe vaccine backbone, we demonstrate here induction of functional immune responses in both arms of adaptive immunity, yielding antiviral efficacy in vivo with the desired immune bias. Consequently, no immunopathologies became evident during challenge experiments. Moreover, the candidate still induces immunity against the measles, recognized as a looming second menace, when countries are forced to stop routine vaccination campaigns in the face of COVID-19. Thus, a bivalent measles-based COVID-19 vaccine could be the solution for two significant public health threats.</jats:p>