Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons

Media type: E-Article
Title: Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons
Contributor: O'Meara, Gillian; Coumis, Urania; Ma, Shuang Y.; Kehr, Jan; Mahoney, Sally; Bacon, Andrea; Allen, Shelley J.; Holmes, Fiona; Kahl, Ulrika; Wang, Fu H.; Kearns, Ian R.; Ove-Ogren, Sven; Dawbarn, David; Mufson, Elliott J.; Davies, Ceri; Dawson, Gerard; Wynick, David
Published: Proceedings of the National Academy of Sciences, 2000
Published in: Proceedings of the National Academy of Sciences, 97 (2000) 21, Seite 11569-11574
Language: English
DOI: 10.1073/pnas.210254597
ISSN: 0027-8424; 1091-6490
Origination:
Footnote:
Description: The neuropeptide galanin colocalizes with choline acetyltransferase, the synthetic enzyme for acetylcholine, in a subset of cholinergic neurons in the basal forebrain of rodents. Chronic intracerebroventricular infusion of nerve growth factor induces a 3- to 4-fold increase in galanin gene expression in these neurons. Here we report the loss of a third of cholinergic neurons in the medial septum and vertical limb diagonal band of the basal forebrain of adult mice carrying a targeted loss-of-function mutation in the galanin gene. These deficits are associated with a 2-fold increase in the number of apoptotic cells in the forebrain at postnatal day seven. This loss is associated with marked age-dependent deficits in stimulated acetylcholine release, performance in the Morris water maze, and induction of long-term potentiation in the CA1 region of the hippocampus. These data provide unexpected evidence that galanin plays a trophic role to regulate the development and function of a subset of septohippocampal cholinergic neurons.
Access State: Open Access

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