Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2

Media type: E-Article
Title: Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2
Contributor: Luo, Wenshu; Egger, Matteo; Domonkos, Andor; Que, Lin; Lukacsovich, David; Cruz-Ochoa, Natalia Andrea; Szőcs, Szilárd; Seng, Charlotte; Arszovszki, Antónia; Sipos, Eszter; Amrein, Irmgard; Winterer, Jochen; Lukacsovich, Tamás; Szabadics, János; Wolfer, David P.; Varga, Csaba; Földy, Csaba
imprint: Proceedings of the National Academy of Sciences, 2021
Published in: Proceedings of the National Academy of Sciences
Language: English
DOI: 10.1073/pnas.2108239118
ISSN: 1091-6490; 0027-8424
Keywords: Multidisciplinary
Origination:
Footnote:
Description: <jats:title>Significance</jats:title> <jats:p>Neurons have an exceptional capacity to grow axons and form synaptic circuits during development but not later life. In adults, the lack of circuit formation may support retention of skilled actions and memories but also limits regeneration and repair after injuries and in disorders. Research on developing and damaged neurons has revealed many molecules that help circuit formation and regeneration, and yet factors that could induce axon growth and synapse formation in adult brain neurons remain elusive. Here, we searched for such key molecules and find one that alone can induce complete circuit formation. After engineering a new circuit in adult mice, we also looked into its function and relevance for memories.</jats:p>
Access State: Open Access

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