Description:
<jats:title>Significance</jats:title><jats:p>A highly intricate architecture of endoplasmic reticulum (ER) membrane is crucial for the organelle functioning. Recent super-resolution microscopy studies discovered a nanoscopic level of ER organization characterized by 10- to 100-nm internal length scales. Deciphering the physical mechanisms of forming the ER nanostructures is a base for understanding the cell control of ER dynamics. Here, we proposed and computationally substantiated a common mechanism of shaping of all currently known ER nanostructures based on the intrinsic membrane curvature and ultra-low tensions as, respectively, a primary and a modulating factor.</jats:p>