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Maestas, David R.; Chung, Liam; Han, Jin; Wang, Xiaokun; Sommerfeld, Sven D.; Kelly, Sean H.; Moore, Erika; Nguyen, Helen Hieu; Mejías, Joscelyn C.; Peña, Alexis N.; Zhang, Hong; Hooks, Joshua S. T.; Chin, Alexander F.; Andorko, James I.; Berlinicke, Cynthia A.; Krishnan, Kavita; Choi, Younghwan; Anderson, Amy E.; Mahatme, Ronak; Mejia, Christopher; Eric, Marie; Woo, JiWon; Ganguly, Sudipto; Zack, Donald J.; [...]

Helminth egg derivatives as proregenerative immunotherapies

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  • Media type: E-Article
  • Title: Helminth egg derivatives as proregenerative immunotherapies
  • Contributor: Maestas, David R.; Chung, Liam; Han, Jin; Wang, Xiaokun; Sommerfeld, Sven D.; Kelly, Sean H.; Moore, Erika; Nguyen, Helen Hieu; Mejías, Joscelyn C.; Peña, Alexis N.; Zhang, Hong; Hooks, Joshua S. T.; Chin, Alexander F.; Andorko, James I.; Berlinicke, Cynthia A.; Krishnan, Kavita; Choi, Younghwan; Anderson, Amy E.; Mahatme, Ronak; Mejia, Christopher; Eric, Marie; Woo, JiWon; Ganguly, Sudipto; Zack, Donald J.; [...]
  • imprint: Proceedings of the National Academy of Sciences, 2023
  • Published in: Proceedings of the National Academy of Sciences
  • Language: English
  • DOI: 10.1073/pnas.2211703120
  • ISSN: 0027-8424; 1091-6490
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:p> The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth <jats:italic>Schistosoma mansoni</jats:italic> soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4-expressing T helper cells, eosinophils, and regulatory T cells and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a regenerative immunotherapy approach using natural helminth derivatives. </jats:p>
  • Access State: Open Access