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Media type:
E-Article
Title:
Nfat
Contributor:
Horsley, Valerie;
Pavlath, Grace K.
Published:
Rockefeller University Press, 2002
Published in:
The Journal of Cell Biology, 156 (2002) 5, Seite 771-774
Language:
English
DOI:
10.1083/jcb.200111073
ISSN:
1540-8140;
0021-9525
Origination:
Footnote:
Description:
The nuclear factor of activated T cells (NFAT) proteins are a family of transcription factors whose activation is controlled by calcineurin, a Ca2+-dependent phosphatase. Originally identified in T cells as inducers of cytokine gene expression, NFAT proteins play varied roles in cells outside of the immune system. This review addresses the recent data implicating NFAT in the control of gene expression influencing the development and adaptation of numerous mammalian cell types.