Heinzel, Amy S.;
Grotzke, Jeff E.;
Lines, Rebecca A.;
Lewinsohn, Deborah A.;
McNabb, Andria L.;
Streblow, Daniel N.;
Braud, Veronique M.;
Grieser, Heather J.;
Belisle, John T.;
Lewinsohn, David M.
HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells
You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells
Contributor:
Heinzel, Amy S.;
Grotzke, Jeff E.;
Lines, Rebecca A.;
Lewinsohn, Deborah A.;
McNabb, Andria L.;
Streblow, Daniel N.;
Braud, Veronique M.;
Grieser, Heather J.;
Belisle, John T.;
Lewinsohn, David M.
imprint:
Rockefeller University Press, 2002
Published in:
The Journal of Experimental Medicine, 196 (2002) 11, Seite 1473-1481
Language:
English
DOI:
10.1084/jem.20020609
ISSN:
1540-9538;
0022-1007
Origination:
Footnote:
Description:
<jats:p>Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.</jats:p>