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Media type:
E-Article
Title:
E-cadherin Surface Levels in Epithelial Growth Factor-stimulated Cells Depend on Adherens Junction Protein Shrew-1
Contributor:
Gross, Julia Christina;
Schreiner, Alexander;
Engels, Knut;
Starzinski-Powitz, Anna
Published:
American Society for Cell Biology (ASCB), 2009
Published in:
Molecular Biology of the Cell, 20 (2009) 15, Seite 3598-3607
Language:
English
DOI:
10.1091/mbc.e08-12-1240
ISSN:
1059-1524;
1939-4586
Origination:
Footnote:
Description:
Gain- and loss-of-function studies indicate that the adherens junction protein shrew-1 acts as a novel modulator of E-cadherin internalization induced by epithelial growth factor (EGF) or E-cadherin function-blocking antibody during epithelial cell dynamics. Knocking down shrew-1 in MCF-7 carcinoma cells preserves E-cadherin surface levels upon EGF stimulation. Overexpression of shrew-1 leads to preformation of an E-cadherin/EGF receptor (EGFR) HER2/src-kinase/shrew-1 signaling complex and accelerated E-cadherin internalization. Shrew-1 is not sufficient to stimulate E-cadherin internalization, but facilitates the actions of EGFR and thus may promote malignant progression in breast cancer cells with constitutive EGFR stimulation by reducing surface E-cadherin expression.