imprint:
American Society for Cell Biology (ASCB), 2018
Published in:Molecular Biology of the Cell
Language:
English
DOI:
10.1091/mbc.e17-01-0027
ISSN:
1059-1524;
1939-4586
Origination:
Footnote:
Description:
<jats:p> Aggregated polypeptides accumulating inside mitochondria are sequestered in a single cellular quality compartment, called IMiQ. Its formation retains proteotoxic aggregates in a distinct cellular localization, increasing mitochondrial fitness by relieving the protein quality control system of misfolded polypeptides. </jats:p>