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Huemer, Marie-Theres; Kluttig, Alexander; Fischer, Beate; Ahrens, Wolfgang; Castell, Stefanie; Ebert, Nina; Gastell, Sylvia; Jöckel, Karl-Heinz; Kaaks, Rudolf; Karch, André; Keil, Thomas; Kemmling, Yvonne; Krist, Lilian; Leitzmann, Michael; Lieb, Wolfgang; Meinke-Franze, Claudia; Michels, Karin B; Mikolajczyk, Rafael; Moreno Velásquez, Ilais; Pischon, Tobias; Schipf, Sabine; Schmidt, Börge; Schöttker, Ben; Schulze, Matthias B; [...]

Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points

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  • Media type: E-Article
  • Title: Grip strength values and cut-off points based on over 200,000 adults of the German National Cohort - a comparison to the EWGSOP2 cut-off points
  • Contributor: Huemer, Marie-Theres; Kluttig, Alexander; Fischer, Beate; Ahrens, Wolfgang; Castell, Stefanie; Ebert, Nina; Gastell, Sylvia; Jöckel, Karl-Heinz; Kaaks, Rudolf; Karch, André; Keil, Thomas; Kemmling, Yvonne; Krist, Lilian; Leitzmann, Michael; Lieb, Wolfgang; Meinke-Franze, Claudia; Michels, Karin B; Mikolajczyk, Rafael; Moreno Velásquez, Ilais; Pischon, Tobias; Schipf, Sabine; Schmidt, Börge; Schöttker, Ben; Schulze, Matthias B; [...]
  • imprint: Oxford University Press (OUP), 2023
  • Published in: Age and Ageing
  • Language: English
  • DOI: 10.1093/ageing/afac324
  • ISSN: 0002-0729; 1468-2834
  • Keywords: Geriatrics and Gerontology ; Aging ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>The European Working Group on Sarcopenia in Older People (EWGSOP) updated in 2018 the cut-off points for low grip strength to assess sarcopenia based on pooled data from 12 British studies.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective</jats:title> <jats:p>Comparison of the EWGSOP2 cut-off points for low grip strength to those derived from a large German sample.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We assessed the grip strength distribution across age and derived low grip strength cut-off points for men and women (peak mean -2.5 × SD) based on 200,389 German National Cohort (NAKO) participants aged 19–75 years. In 1,012 Cooperative Health Research in the Region of Augsburg (KORA)-Age participants aged 65–93 years, we calculated the age-standardised prevalence of low grip strength and time-dependent sensitivity and specificity for all-cause mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Grip strength increased in the third and fourth decade of life and declined afterwards. Calculated cut-off points for low grip strength were 29 kg for men and 18 kg for women. In KORA-Age, the age-standardised prevalence of low grip strength was 1.5× higher for NAKO-derived (17.7%) compared to EWGSOP2 (11.7%) cut-off points. NAKO-derived cut-off points yielded a higher sensitivity and lower specificity for all-cause mortality.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Cut-off points for low grip strength from German population-based data were 2 kg higher than the EWGSOP2 cut-off points. Higher cut-off points increase the sensitivity, thereby suggesting an intervention for more patients at risk, while other individuals might receive additional diagnostics/treatment without the urgent need. Research on the effectiveness of intervention in patients with low grip strength defined by different cut-off points is needed.</jats:p> </jats:sec>
  • Access State: Open Access