Description:
<jats:title>Abstract</jats:title>
<jats:p>The Targeted Risk Assessment tool (TRA) has been widely used since 2010 in the development of REACH registration dossiers for classified chemical substances to estimate worker exposures (inhalation, dermal) across manufacturing and use operations in supply chains in Europe. The TRA is a Tier-1 tool which produces simplified exposure predictions based on limited inputs and intended to be conservative. The current version (3.1) of the TRA was released in 2012 and has been built into ECHA’s CHESAR tool. A number of studies have been published of TRA-generated exposure predictions compared with workplace measurement data and presenting conclusions about the tool performance. Most publications covered only a subset of the tool outputs. A group of ECETOC exposure assessors assembled inventories of published comparisons over the period of 2010-2020 (approximately 120 workplace scenarios for long-term inhalation, 40 scenarios for peak inhalation and 80 scenarios for dermal exposure) to systematically review the tool performance. The analysis has allowed to draw more robust conclusions about the performance of specific aspects of the tool, such as base level estimates and effectiveness of local exhaust ventilation, to either reinforce the conclusions of conservatism (majority of scenarios) or recommend changes to tool settings in a future version (minority of cases) to better match the tool’s intent. A short overview of the comparisons will be presented, as well as the planned changes to the tool settings.</jats:p>