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Media type:
E-Article
Title:
ASimulatoR: splice-aware RNA-Seq data simulation
Contributor:
Manz, Quirin;
Tsoy, Olga;
Fenn, Amit;
Baumbach, Jan;
Völker, Uwe;
List, Markus;
Kacprowski, Tim
imprint:
Oxford University Press (OUP), 2021
Published in:Bioinformatics
Language:
English
DOI:
10.1093/bioinformatics/btab142
ISSN:
1367-4803;
1367-4811
Origination:
Footnote:
Description:
<jats:title>Abstract</jats:title>
<jats:sec>
<jats:title>Summary</jats:title>
<jats:p>A plethora of tools exist for RNA-Seq data analysis with a focus on alternative splicing (AS). However, appropriate data for their comparative evaluation is missing. The R package ASimulatoR simulates gold standard RNA-Seq datasets with fine-grained control over the distribution of AS events, which allow for evaluating alternative splicing tools, e.g. to study the effect of sequencing depth on the performance of AS event detection.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Availability and implementation</jats:title>
<jats:p>ASimulatoR is freely available at https://github.com/biomedbigdata/ASimulatoR as an R package under GPL-3 license.</jats:p>
</jats:sec>