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Betton, Maureen; Livrozet, Marine; Planas, Delphine; Fayol, Antoine; Monel, Blandine; Védie, Benoit; Bruel, Timothée; Tartour, Eric; Robillard, Nicolas; Manuguerra, Jean-Claude; Blanchard, Anne; Ghosn, Jade; Visseaux, Benoit; Péré, Hélène; Lebeaux, David; Schwartz, Olivier; Veyer, David; Hulot, Jean-Sébastien; Abel, Laurent; Andrejak, Claire; Angoulvant, François; Bachelet, Delphine; Bhavsar, Krishna; Bouadma, Lila; [...]

Sera Neutralizing Activities Against Severe Acute Respiratory Syndrome Coronavirus 2 and Multiple Variants 6 Months After Hospitalization for Coronavirus Disease 2019

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  • Media type: E-Article
  • Title: Sera Neutralizing Activities Against Severe Acute Respiratory Syndrome Coronavirus 2 and Multiple Variants 6 Months After Hospitalization for Coronavirus Disease 2019
  • Contributor: Betton, Maureen; Livrozet, Marine; Planas, Delphine; Fayol, Antoine; Monel, Blandine; Védie, Benoit; Bruel, Timothée; Tartour, Eric; Robillard, Nicolas; Manuguerra, Jean-Claude; Blanchard, Anne; Ghosn, Jade; Visseaux, Benoit; Péré, Hélène; Lebeaux, David; Schwartz, Olivier; Veyer, David; Hulot, Jean-Sébastien; Abel, Laurent; Andrejak, Claire; Angoulvant, François; Bachelet, Delphine; Bhavsar, Krishna; Bouadma, Lila; [...]
  • imprint: Oxford University Press (OUP), 2021
  • Published in: Clinical Infectious Diseases
  • Language: English
  • DOI: 10.1093/cid/ciab308
  • ISSN: 1058-4838; 1537-6591
  • Keywords: Infectious Diseases ; Microbiology (medical)
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs within the first weeks after coronavirus disease 2019 (COVID-19). Those antibodies exert a neutralizing activity against SARS-CoV-2, whose evolution over time after COVID-19 as well as efficiency against novel variants are poorly characterized.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>In this prospective study, sera of 107 patients hospitalized with COVID-19 were collected at 3 and 6 months postinfection. We performed quantitative neutralization experiments on top of high-throughput serological assays evaluating anti-spike (S) and anti-nucleocapsid (NP) immunoglobulin G (IgG).</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Levels of seroneutralization and IgG rates against the ancestral strain decreased significantly over time. After 6 months, 2.8% of the patients had a negative serological status for both anti-S and anti-NP IgG. However, all sera had a persistent and effective neutralizing effect against SARS-CoV-2. IgG levels correlated with seroneutralization, and this correlation was stronger for anti-S than for anti-NP antibodies. The level of seroneutralization quantified at 6 months correlated with markers of initial severity, notably admission to intensive care units and the need for mechanical invasive ventilation. In addition, sera collected at 6 months were tested against multiple SARS-CoV-2 variants and showed efficient neutralizing effects against the D614G, B.1.1.7, and P.1 variants but significantly weaker activity against the B.1.351 variant.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Decrease in IgG rates and serological assays becoming negative did not imply loss of neutralizing capacity. Our results indicate a sustained humoral response against the ancestral strain and the D614G, B.1.1.7, and P.1 variants for at least 6 months in patients previously hospitalized for COVID-19. A weaker protection was, however, observed for the B.1.351 variant.</jats:p> </jats:sec>
  • Access State: Open Access