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Tadesse, Birkneh Tilahun; Bravo, Lulu; Marks, Florian; Aziz, Asma Binte; You, Young Ae; Sugimoto, Jonathan; Li, Ping; Garcia, Joyce; Rockhold, Frank; Clemens, Ralf; Roa, Camilo; Borja-Tabora, Charissa; Carlos, Josefina; Montellano, May Emmeline B; Reyes, Mari Rose A de Los; Alberto, Edison R; Salvani-Bautista, Milagros; Kim, Deok Ryun; Kim, Hwa Young; Hong, Sye Lim; Kang, Sophie S Y; Njau, Irene

Impact of Vaccination With the SCB-2019 Coronavirus Disease 2019 Vaccine on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Household Contact Study in the Philippines

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  • Media type: E-Article
  • Title: Impact of Vaccination With the SCB-2019 Coronavirus Disease 2019 Vaccine on Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Household Contact Study in the Philippines
  • Contributor: Tadesse, Birkneh Tilahun; Bravo, Lulu; Marks, Florian; Aziz, Asma Binte; You, Young Ae; Sugimoto, Jonathan; Li, Ping; Garcia, Joyce; Rockhold, Frank; Clemens, Ralf; Roa, Camilo; Borja-Tabora, Charissa; Carlos, Josefina; Montellano, May Emmeline B; Reyes, Mari Rose A de Los; Alberto, Edison R; Salvani-Bautista, Milagros; Kim, Deok Ryun; Kim, Hwa Young; Hong, Sye Lim; Kang, Sophie S Y; Njau, Irene
  • Published: Oxford University Press (OUP), 2023
  • Published in: Clinical Infectious Diseases, 76 (2023) 7, Seite 1180-1187
  • Language: English
  • DOI: 10.1093/cid/ciac914
  • ISSN: 1058-4838; 1537-6591
  • Origination:
  • Footnote:
  • Description: AbstractBackgroundAn exploratory household transmission study was nested in SPECTRA, the phase 2/3 efficacy study of the adjuvanted recombinant protein-based COVID-19 vaccine SCB-2019. We compared the occurrence of confirmed COVID-19 infections between households and household contacts of infected SPECTRA placebo or SCB-2019 recipients.MethodsSPECTRA participants at 8 study sites in the Philippines who developed real-time reverse transcriptase–polymerase chain reaction (rRT-PCR)–confirmed COVID-19 were contacted by a study team blinded to assignment of index cases to vaccine or placebo groups to enroll in this household transmission study. Enrolled households and household contacts were monitored for 3 weeks using rRT-PCR and anti–SARS-CoV-2 N-antigen IgG/IgM testing to detect new COVID-19 infections.ResultsOne hundred fifty-four eligible COVID-19 index cases (51 vaccinees, 103 placebo) were included. The secondary attack rate per household for symptomatic COVID-19 infection was 0.76% (90% CI: .15–3.90%) if the index case was an SCB-2019 vaccinee compared with 5.88% (90% CI: 3.20–10.8%) for placebo index cases, a relative risk reduction (RRR) of 79% (90% CI: −28% to 97%). The RRR of symptomatic COVID-19 per household member was similar: 84% (90% CI: 28–97%). The impact on attack rates in household members if index cases were symptomatic (n = 130; RRR = 80%; 90% CI: 7–96%) or asymptomatic (n = 24; RRR = 100%; 90% CI: −76% to 100%) was measurable but the low numbers undermine the clinical significance.ConclusionsIn this prospective household contact study vaccination with SCB-2019 reduced SARS-CoV-2 transmission compared with placebo in households and in household members independently of whether or not index cases were symptomatic.
  • Access State: Open Access