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Al’Aref, Subhi J; Altibi, Ahmed M; Malkawi, Abdallah; Mansour, Munthir; Baskaran, Lohendran; Masri, Ahmad; Rahmouni, Hind; Abete, Raffaele; Andreini, Daniele; Aquaro, Giovanni; Barison, Andrea; Bogaert, Jan; Camastra, Giovanni; Carigi, Samuela; Carrabba, Nazario; Casavecchia, Grazia; Censi, Stefano; Cicala, Gloria; Conte, Edoardo; De Cecco, Carlo N; De Lazzari, Manuel; Di Giovine, Gabriella; Di Roma, Mauro; Dobrovie, Monica; [...]

Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy

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  • Media type: E-Article
  • Title: Cardiac magnetic resonance for prophylactic implantable-cardioverter defibrillator therapy international study: prognostic value of cardiac magnetic resonance-derived right ventricular parameters substudy
  • Contributor: Al’Aref, Subhi J; Altibi, Ahmed M; Malkawi, Abdallah; Mansour, Munthir; Baskaran, Lohendran; Masri, Ahmad; Rahmouni, Hind; Abete, Raffaele; Andreini, Daniele; Aquaro, Giovanni; Barison, Andrea; Bogaert, Jan; Camastra, Giovanni; Carigi, Samuela; Carrabba, Nazario; Casavecchia, Grazia; Censi, Stefano; Cicala, Gloria; Conte, Edoardo; De Cecco, Carlo N; De Lazzari, Manuel; Di Giovine, Gabriella; Di Roma, Mauro; Dobrovie, Monica; [...]
  • imprint: Oxford University Press (OUP), 2023
  • Published in: European Heart Journal - Cardiovascular Imaging
  • Language: English
  • DOI: 10.1093/ehjci/jeac124
  • ISSN: 2047-2404; 2047-2412
  • Keywords: Cardiology and Cardiovascular Medicine ; Radiology, Nuclear Medicine and imaging ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>Aims</jats:title><jats:p>Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF).</jats:p></jats:sec><jats:sec><jats:title>Methods and results</jats:title><jats:p>Study cohort comprised of patients enrolled in the CarDiac MagnEtic Resonance for Primary Prevention Implantable CardioVerter DefibrillAtor ThErapy registry who had HFrEF and had simultaneous baseline CMR and echocardiography (n = 2449). RVSD was defined as RV ejection fraction (RVEF) &amp;lt;45%. Kaplan–Meier curves and cox regression were used to investigate the association between RVSD and all-cause mortality (ACM). Mean age was 59.8 ± 14.0 years, 42.0% were female, and mean left ventricular ejection fraction (LVEF) was 34.0 ± 10.8. Median follow-up was 959 days (interquartile range: 560–1590). RVSD was present in 936 (38.2%) and was an independent predictor of ACM (adjusted hazard ratio = 1.44; 95% CI [1.09–1.91]; P = 0.01). On subgroup analyses, the prognostic value of RVSD was more pronounced in NYHA I/II than in NYHA III/IV, in LVEF &amp;lt;35% than in LVEF ≥35%, and in patients with renal dysfunction when compared to those with normal renal function.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>RV systolic dysfunction is an independent predictor of ACM in HFrEF, with a more pronounced prognostic value in select subgroups, likely reflecting the importance of RVSD in the early stages of HF progression.</jats:p></jats:sec>
  • Access State: Open Access