> Details
Lengelé, Laetitia;
Rolland, Yves;
Martinez, Laurent O;
Guyonnet, Sophie;
Parini, Angelo;
Lucas, Alexandre;
Vellas, Bruno;
Barreto, Philipe de Souto;
Vellas, Bruno;
Guyonnet, Sophie;
Carrié, Isabelle;
Brigitte, Lauréane;
Faisant, Catherine;
Lala, Françoise;
Delrieu, Julien;
Villars, Hélène;
Combrouze, Emeline;
Badufle, Carole;
Zueras, Audrey;
Andrieu, Sandrine;
Cantet, Christelle;
Morin, Christophe;
Van Kan, Gabor Abellan;
Dupuy, Charlotte;
[...]
Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study
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- Media type: E-Article
- Title: Longitudinal Associations Between ATPase Inhibitory Factor 1, Growth Differentiation Factor-15, and Nutritional Status in Older Adults From the MAPT Study
- Contributor: Lengelé, Laetitia; Rolland, Yves; Martinez, Laurent O; Guyonnet, Sophie; Parini, Angelo; Lucas, Alexandre; Vellas, Bruno; Barreto, Philipe de Souto; Vellas, Bruno; Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Villars, Hélène; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Andrieu, Sandrine; Cantet, Christelle; Morin, Christophe; Van Kan, Gabor Abellan; Dupuy, Charlotte; [...]
- imprint: Oxford University Press (OUP), 2024
- Published in: The Journals of Gerontology: Series A
- Language: English
- DOI: 10.1093/gerona/glad236
- ISSN: 1079-5006; 1758-535X
- Keywords: Geriatrics and Gerontology ; Aging
- Origination:
- Footnote:
- Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>GDF-15 plasma levels were related to key malnutrition criteria.</jats:p> </jats:sec>