> Details

Kaminski, Hannah; Ménard, Coline; El Hayani, Bouchra; Adjibabi, And-Nan; Marsères, Gabriel; Courant, Maxime; Zouine, Atika; Pitard, Vincent; Garrigue, Isabelle; Burrel, Sonia; Moreau, Jean-François; Couzi, Lionel; Visentin, Jonathan; Merville, Pierre; Déchanet-Merville, Julie

Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity
  • Contributor: Kaminski, Hannah; Ménard, Coline; El Hayani, Bouchra; Adjibabi, And-Nan; Marsères, Gabriel; Courant, Maxime; Zouine, Atika; Pitard, Vincent; Garrigue, Isabelle; Burrel, Sonia; Moreau, Jean-François; Couzi, Lionel; Visentin, Jonathan; Merville, Pierre; Déchanet-Merville, Julie
  • imprint: Oxford University Press (OUP), 2021
  • Published in: The Journal of Infectious Diseases
  • Language: English
  • DOI: 10.1093/infdis/jiaa400
  • ISSN: 0022-1899; 1537-6613
  • Keywords: Infectious Diseases ; Immunology and Allergy
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title> <jats:p>Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the Vγ9posVδ2pos T cells that respond to phosphoantigens but not to CMV. A third Vγ9negVδ2pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these Vγ9negVδ2pos T cells are also components of the CMV immune response while presenting with distinct characteristics from Vδ2neg γδ T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with Vγ9negVδ2pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, Vγ9negVδ2pos T cells responded specifically to CMV-infected cells in a T-cell receptor–dependent manner and through strong interferon γ production. Finally, Vγ9negVδ2pos T cells were the only γδ T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using Vγ9negVδ2pos T cells as an immune marker for CMV disease severity in immunocompromised patients.</jats:p>
  • Access State: Open Access