> Details
Goupil de Bouillé, Jeanne;
Vigouroux, Corinne;
Plessis, Lorraine;
Ghislain, Mathilde;
Teglas, Jean-Paul;
Boufassa, Faroudy;
Goujard, Cécile;
Vignes, Dorothée;
Bouchaud, Olivier;
Salmon, Dominique;
Meyer, Laurence;
Abgrall, Sophie;
B., O;
B., F;
Carlier, Robert;
Dray-Spira, Rosemary;
G., M;
G., C;
P., L;
Marchand, Lucie;
M., L;
Petrov-Sanchez, Ventzislava;
P., L;
Rouzioux, Christine;
[...]
Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers
Sharing
Reference
management
Direct link
Bookmarks
Remove from
bookmarks
Share this by email
Share this on Twitter
Share this on Facebook
Share this on Whatsapp
- Media type: E-Article
- Title: Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers
- Contributor: Goupil de Bouillé, Jeanne; Vigouroux, Corinne; Plessis, Lorraine; Ghislain, Mathilde; Teglas, Jean-Paul; Boufassa, Faroudy; Goujard, Cécile; Vignes, Dorothée; Bouchaud, Olivier; Salmon, Dominique; Meyer, Laurence; Abgrall, Sophie; B., O; B., F; Carlier, Robert; Dray-Spira, Rosemary; G., M; G., C; P., L; Marchand, Lucie; M., L; Petrov-Sanchez, Ventzislava; P., L; Rouzioux, Christine; [...]
- imprint: Oxford University Press (OUP), 2021
- Published in: The Journal of Infectious Diseases
- Language: English
- DOI: 10.1093/infdis/jiab151
- ISSN: 0022-1899; 1537-6613
- Keywords: Infectious Diseases ; Immunology and Allergy
- Origination:
- Footnote:
- Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>We investigated the association between socioclinical, inflammatory, and metabolic markers and weight gain in people with human immunodeficiency virus (HIV) on combination antiretroviral therapy (cART).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Individuals from the COPANA cohort of normal weight (body mass index [BMI], 18.5–24.9 [ calculated as weight in kilograms divided by height in meters squared) at cART initiation who achieved virological suppression (viral load, &lt;50 copies/mL) and maintained it through 36 months of treatment were selected. Clinical, immunovirological, and socioeconomic data and inflammation (high-sensitivity C-reactive protein, CXCL10, CXCL8, interleukin 6, soluble tumor necrosis factor receptors 1 and 2, soluble CD14, and soluble CD16) and serum metabolic (glucose, insulin, lipid profile, adiponectin, and leptin) markers were assessed. Factors associated with becoming overweight (BMI, 25–29.9) or obese (BMI, ≥30) at 36 months were assessed using multivariate logistic regression models.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>After 36 months of cART, 32 of 158 people with HIV (20%) became overweight or obese (21% female; 65% born in France and 23% born in sub-Saharan Africa; median BMI at cART initiation, 22 [interquartile range, 21–23]). After adjustment, higher BMI, originating from sub-Saharan Africa, living in a couple, and higher soluble tumor necrosis factor receptor 2 and lower adiponectin concentrations at cART initiation were associated with becoming overweight or obese.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>Weight gain on cART is multifactorial. Special attention should be given to migrants from sub-Saharan Africa. Monocyte activation and adipocyte dysfunction at cART initiation affect weight regulation.</jats:p> </jats:sec>
- Access State: Open Access