Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease

Media type: E-Article
Title: Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease
Contributor: Kruglova, Maria Petrovna; Grachev, Sergej Vital’evich; Bulgakova, Polina Olegovna; Ivanov, Alexander Vladimirovich; Virus, Edward Danielevich; Nikiforova, Ksenya Alexandrovna; Fedoseev, Anatolij Nikolaevich; Savina, Galina Dmitrievna; Kubatiev, Aslan Amirkhanovich
imprint: Oxford University Press (OUP), 2020
Published in: Laboratory Medicine
Language: English
DOI: 10.1093/labmed/lmz035
ISSN: 0007-5027; 1943-7730
Keywords: Biochemistry (medical) ; Clinical Biochemistry
Origination:
Footnote:
Description: <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Objective</jats:title> <jats:p>To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Case-control study including 50 patients with CKD and 20 healthy volunteers.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P &lt;.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.</jats:p> </jats:sec>
Access State: Open Access

Search in field:

Recently searched for: