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Steinbrenner, Inga; Sekula, Peggy; Kotsis, Fruzsina; von Cube, Maja; Cheng, Yurong; Nadal, Jennifer; Schmid, Matthias; Schneider, Markus P; Krane, Vera; Nauck, Matthias; Eckardt, Kai-Uwe; Schultheiss, Ulla T; Eckardt, Kai-Uwe; Meiselbach, Heike; Schneider, Markus P; Schiffer, Mario; Prokosch, Hans-Ulrich; Bärthlein, Barbara; Beck, Andreas; Reis, André; Ekici, Arif B; Becker, Susanne; Becker-Grosspitsch, Dinah; Alberth-Schmidt, Ulrike; [...]

Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study

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  • Media type: E-Article
  • Title: Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study
  • Contributor: Steinbrenner, Inga; Sekula, Peggy; Kotsis, Fruzsina; von Cube, Maja; Cheng, Yurong; Nadal, Jennifer; Schmid, Matthias; Schneider, Markus P; Krane, Vera; Nauck, Matthias; Eckardt, Kai-Uwe; Schultheiss, Ulla T; Eckardt, Kai-Uwe; Meiselbach, Heike; Schneider, Markus P; Schiffer, Mario; Prokosch, Hans-Ulrich; Bärthlein, Barbara; Beck, Andreas; Reis, André; Ekici, Arif B; Becker, Susanne; Becker-Grosspitsch, Dinah; Alberth-Schmidt, Ulrike; [...]
  • imprint: Oxford University Press (OUP), 2023
  • Published in: Nephrology Dialysis Transplantation
  • Language: English
  • DOI: 10.1093/ndt/gfac173
  • ISSN: 0931-0509; 1460-2385
  • Origination:
  • Footnote:
  • Description: <jats:title>ABSTRACT</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Osteopontin (OPN), synthesized in the thick ascending limb of Henle's loop and in the distal tubule, is involved in the pathogenesis of kidney fibrosis, a hallmark of kidney failure (KF). In a cohort of chronic kidney disease (CKD) patients, we evaluated OPN's association with kidney markers and KF.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>OPN was measured from baseline serum samples of German Chronic Kidney Disease study participants. Cross-sectional regression models for estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) as well as Cox regression models for all-cause mortality and KF were evaluated to estimate the OPN effect. Additionally, the predictive ability of OPN and time-dependent population-attributable fraction were evaluated.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Over a median follow-up of 6.5 years, 471 KF events and 629 deaths occurred among 4950 CKD patients. One-unit higher log(OPN) was associated with 5.5 mL/min/1.73 m2 lower eGFR [95% confidence interval (95% CI) –6.4 to –4.6] and 1% change in OPN with 0.7% higher UACR (estimated effect 0.7, 95% CI 0.6–0.8). Moreover, higher OPN levels were associated with a higher risk of KF [hazard ratio (HR) 1.4, 95% CI 1.2–1.7] and all-cause mortality (HR 1.5, 95% CI 1.3–1.8). After 6 years, 31% of the KF events could be attributed to higher OPN levels (95% CI 3%–56%).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>In this study, higher OPN levels were associated with kidney function markers worsening and a higher risk for adverse outcomes. A larger proportion of KF could be attributed to higher OPN levels, warranting further research on OPN with regards to its role in CKD progression and possible treatment options.</jats:p> </jats:sec>