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Quiroga, Borja; Soler, María José; Ortiz, Alberto; Jarava Mantecón, Carlos Jesús; Gomes Pérez, Virginia Olinda; Bordils, Antoni; Lacueva, José; Marin Franco, Antonio José; Delgado Conde, Pablo; Muñoz Ramos, Patricia; Calderón González, Carmen; Cazorla López, Juan Manuel; Sanchez-Rodriguez, Jinny; Sánchez Horrillo, Ana; Monzón Vázquez, Tania Raquel; Leyva, Alba; Rojas, José; Gansevoort, Ron T; de Sequera, Patricia; Rodríguez, María Teresa Jaldo; Valverde, Rafael Lucena; Carretero, Marta Puerta; Díaz, Mayra Ortega; Tocora, Daniel Gaitán; [...]

Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum: a prespecified analysis of the SENCOVAC study

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  • Media type: E-Article
  • Title: Humoral response after the fourth dose of the SARS-CoV-2 vaccine in the CKD spectrum: a prespecified analysis of the SENCOVAC study
  • Contributor: Quiroga, Borja; Soler, María José; Ortiz, Alberto; Jarava Mantecón, Carlos Jesús; Gomes Pérez, Virginia Olinda; Bordils, Antoni; Lacueva, José; Marin Franco, Antonio José; Delgado Conde, Pablo; Muñoz Ramos, Patricia; Calderón González, Carmen; Cazorla López, Juan Manuel; Sanchez-Rodriguez, Jinny; Sánchez Horrillo, Ana; Monzón Vázquez, Tania Raquel; Leyva, Alba; Rojas, José; Gansevoort, Ron T; de Sequera, Patricia; Rodríguez, María Teresa Jaldo; Valverde, Rafael Lucena; Carretero, Marta Puerta; Díaz, Mayra Ortega; Tocora, Daniel Gaitán; [...]
  • imprint: Oxford University Press (OUP), 2023
  • Published in: Nephrology Dialysis Transplantation
  • Language: English
  • DOI: 10.1093/ndt/gfac307
  • ISSN: 0931-0509; 1460-2385
  • Origination:
  • Footnote:
  • Description: <jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>There is scarce evidence on the fourth dose of severe acute respiratory syndrome coronavirus 2 vaccines in chronic kidney disease (CKD) patients. We evaluated the humoral response and effectivity of the fourth dose in the CKD spectrum: non-dialysis CKD (ND-CKD), haemodialysis (HD), peritoneal dialysis (PD) and kidney transplant (KT) recipients.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This is a prespecified analysis of the prospective, observational, multicentric SENCOVAC study. In patients with CKD who had received a complete initial vaccination and one or two boosters and had anti-Spike antibody determinations 6 and 12 months after the initial vaccination, we analysed factors associated with persistent negative humoral response and higher anti-Spike antibody titres as well as the efficacy of vaccination on coronavirus disease 2019 (COVID-19) severity.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 2186 patients (18% KT, 8% PD, 69% HD and 5% ND-CKD), 30% had received a fourth dose. The fourth dose increased anti-Spike antibody titres in HD (P = .001) and ND-CKD (P = .014) patients and seroconverted 72% of previously negative patients. Higher anti-Spike antibody titres at 12 months were independently associated with repeated exposure to antigen (fourth dose, previous breakthrough infections), previous anti-Spike antibody titres and not being a KT recipient. Breakthrough COVID-19 was registered in 137 (6%) patients, 5% of whom required admission. Admitted patients had prior titres &amp;lt;620 UI/ml and median values were lower (P = .020) than in non-admitted patients.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>A fourth vaccine dose increased anti-Spike antibody titres or seroconverted many CKD patients, but those with the highest need for a vaccine booster (i.e. those with lower pre-booster antibody titres or KT recipients) derived the least benefit in terms of antibody titres. Admission for breakthrough COVID-19 was associated with low anti-Spike antibody titres.</jats:p></jats:sec>
  • Access State: Open Access