Description:
<jats:sec><jats:label /><jats:p>This study evaluated the relationship between obesity and prostate cancer aggressiveness using data from the North Carolina ‐ Louisiana Prostate Cancer Project, a population‐based study of incident prostate cancer. Medical record data was used to classify 1793 subjects for prostate cancer aggressiveness at diagnosis using clinical criteria. An association was sought between prostate cancer aggressiveness and body mass index (BMI) and waist‐to‐hip ratio (WHR). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression adjusted for confounders with race considered as an effect modifier. A strong positive association was found between prostate cancer aggressiveness and both BMI and WHR among Caucasian Americans (CA). The ORs among CA for high aggressive prostate cancer among obese and severely obese were 2.51 (95%CI=1.27, 4.97) and 3.47 (95%CI=1.65, 7.31), respectively, compared to normal weight subjects. African Americans (AA) had more aggressive prostate cancer compared to CA (OR = 2.55 [95%CI=1.26, 5.17] for normal weight AA versus normal weight CA), but increased obesity was not associated with increased risk of high aggressive prostate cancer. In conclusion, the relationship between obesity and aggressive prostate cancer is apparent among CA, but the relationship among AA deserves further investigation. Grant Sponsor: Department of Defense DAMD 17‐03‐2‐0052</jats:p></jats:sec>