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Media type:
E-Article
Title:
Association of food intake with prostate cancer aggressiveness of African and Caucasian Americans in a population‐based study
Contributor:
Vance, Terrence M;
Wang, Ying;
Su, L. Joseph;
Fontham, Elizabeth T. H.;
Bensen, Jeannette T.;
Mohler, James L.;
Chen, Ming‐Hui;
Chun, Ock K.
Description:
This study aimed to determine the association between major food groups that contribute to antioxidant intake and prostate cancer aggressiveness (PCA). Data are from the North Carolina‐Louisiana Prostate Cancer Project, a study of incident prostate cancer in African Americans (AA) (n=925) and Caucasian Americans (CA) (n=1,059). Dietary data were collected by a modified NCI DHQ. Prostate cancer cases were classified as low aggressive (LA) (Gleason score <7, stage ≤T2, PSA <10 ng/ml), high aggressive (HA) (Gleason score ≥8; PSA ≥20 ng/ml; or Gleason score = 7 if stage ≥T3), or intermediate aggressive (IA) (others). AA consuming 1 to 2 cups of fruit drink a week were found to have an odds ratio (OR) for HA vs. LA of 0.43 (95% CI: 0.20, 0.96) and 1 to 2 glasses of wine a week were found to have an OR for IA vs. LA of 0.30 (95% CI: 0.09, 1.00). CA drinking >;2 cups a day of tea were found to have an OR for HA vs. LA of OR 0.44 (95% CI: 0.20, 0.94) and 1 to 2 cups a week of orange juice were found to have an OR for IA vs. LA of OR 0.52 (95% CI: 0.27, 0.98). These results imply that antioxidant rich foods may contribute differently to PCA in CA and AA.Grant Funding Source: NIH Cancer Epidemiology Small Grant #1R03CA159421–01A1.