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Gozdalski, Jacek; Nowicki, Tomasz; Kwarciany, Mariusz; Kowalczyk, Kamil; Narkiewicz, Krzysztof; Gasecki, Dariusz

AORTIC STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH INTRACRANIAL CAROTID ARTERY CALCIFICATION IN PATIENTS WITH ISCHEMIC STROKE

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  • Media type: E-Article
  • Title: AORTIC STIFFNESS IS INDEPENDENTLY ASSOCIATED WITH INTRACRANIAL CAROTID ARTERY CALCIFICATION IN PATIENTS WITH ISCHEMIC STROKE
  • Contributor: Gozdalski, Jacek; Nowicki, Tomasz; Kwarciany, Mariusz; Kowalczyk, Kamil; Narkiewicz, Krzysztof; Gasecki, Dariusz
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2023
  • Published in: Journal of Hypertension
  • Language: English
  • DOI: 10.1097/01.hjh.0000942168.42404.bc
  • ISSN: 0263-6352; 1473-5598
  • Keywords: Cardiology and Cardiovascular Medicine ; Physiology ; Internal Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Objective:</jats:title> <jats:p>Intracranial carotid artery calcification (ICAC), as a strong contributor to the occurrence of ischemic stroke, might be present in the medial or intimal arterial layer. Traditional vascular risk factors are associated with ICAC; however, its association with new markers of vascular function are less understood. The paper aims to evaluate the relationship between carotid-femoral pulse wave velocity (CF-PWV) and ICAC subtypes.</jats:p> </jats:sec> <jats:sec> <jats:title>Design and method:</jats:title> <jats:p>We enrolled 65 patients with acute ischemic stroke. CF-PWV, systolic, diastolic and mean blood pressure, and pulse pressure (SBP, DBP, MBP, PP) were measured within 6±2 days of stroke onset.</jats:p> <jats:p>CT was performed within 24 hours of stroke onset and ICAC on the stroke site was classified by two methods: volume- and score-based. Tertiles of ICAC volume were determined, and low-grade ICAC (T1) was regarded as a reference. According to the score-based method, medial and intimal ICAC subtypes were determined. Data were analyzed with multivariate logistic regression.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Medial and intimal ICAC subtypes were found in 34 (52%) and 24 (37%) patients, respectively. In 11% of patients no ICAC calcifications were found. CF-PWV was higher in patients with high-grade ICAC (OR = 1.56, 95%CI = 1.03-2.35, p = 0.035). CF-PWV was higher in patients with the medial ICAC subtype than in patients with the intimal ICAC subtype (OR = 1.60, 95%CI = 1.00-2.55, p = 0.049) after adjustment for age, MBP, diabetes mellitus, arterial hypertension, hyperlipidemia, and smoking status.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Our study demonstrates that among patients with ischemic stroke, aortic stiffness is independently associated with ICAC, and that medial ICAC, compared with intimal ICAC, is accompanied by more advanced aortic stiffness.</jats:p> </jats:sec>