Description:
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<jats:title>Objective:</jats:title>
<jats:p>Urine protein is one of the important indicators of renal failure. Generally, In high blood pressure, diabetes, urinary protein excretion tends to increase with poor control and renal dysfunction, but the difference between individuals is very large. This suggests that there are some genetic factors for urinary protein excretion. We performed a genome-wide association study (GWAS) on urinary protein excretion using data from 10,000 Japanese people and reported 18 SNPs related to urinary albumin excretion. (Clin Exp Nephrol. 2020 Aug; 24 (8)). This time, we increased the number of samples and analyzed using the data of 67,000 Japanese people.</jats:p>
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<jats:title>Design and method:</jats:title>
<jats:p>GWAS was performed using approximately 680,000 single nucleotide polymorphism (SNP) data obtained from 67,000 TMM health survey participants collected from 2013 to 2020. As covariates, age, gender, BMI, blood pressure, renal function (calculated by blood CysC), and HbA1c were used. Imputation was performed using a haplotype panel consisting of whole-genome sequence data of 2000 people, and further analysis was performed on the data, and allele frequency and INFO value after imputation were adjusted.</jats:p>
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<jats:title>Results:</jats:title>
<jats:p>The analysis results were examined with p < 5 × 10 <jats:sup>−8</jats:sup> as the significance level, and novel SNPs related in urine protein excretion were identified on chromosome 6. The identified SNPs were found in regions associated with potassium metabolism.</jats:p>
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<jats:title>Conclusions:</jats:title>
<jats:p>The identified SNPs are considered to have some effect on urinary protein excretion. It is necessary to consider the mechanism and further verify it.</jats:p>
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