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Parolini, Barbara; Di Salvatore, Attilio; Pinackatt, Sajish Joseph; Baldi, Andrea; Besozzi, Gianluca; Finzi, Alessandro; Cardillo, Daniele; Sallam, Ahmed B.; Frisina, Rino

LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES

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  • Media type: E-Article
  • Title: LONG-TERM RESULTS OF AUTOLOGOUS RETINAL PIGMENT EPITHELIUM AND CHOROID TRANSPLANTATION FOR THE TREATMENT OF EXUDATIVE AND ATROPHIC MACULOPATHIES
  • Contributor: Parolini, Barbara; Di Salvatore, Attilio; Pinackatt, Sajish Joseph; Baldi, Andrea; Besozzi, Gianluca; Finzi, Alessandro; Cardillo, Daniele; Sallam, Ahmed B.; Frisina, Rino
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2020
  • Published in: Retina
  • Language: English
  • DOI: 10.1097/iae.0000000000002429
  • ISSN: 0275-004X
  • Keywords: Ophthalmology ; General Medicine
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Purpose:</jats:title> <jats:p>To evaluate the long-term results of autologous retinal pigment epithelium (RPE) and choroid transplantation (RPE–choroid patch) for exudative and atrophic maculopathies.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Consecutive chart review of 120 eyes, which underwent RPE–choroid patch, from 2007 to 2017 for RPE atrophy or choroidal neovascular membrane secondary to exudative and hemorrhagic age-related macular degeneration, myopia, angioid streaks, and laser. Eyes were tested with best-corrected visual acuity (BCVA), reading ability, optical coherence tomography, fluorescein angiography and indocyanine green angiography, autofluorescence, and microperimetry.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Eighty-eight eyes of 84 patients had complete data, with 2- to 10-year follow-up. Mean age was 71.9 ± 9.06 years. Mean preoperative and postoperative BCVA was 20/320 (1.2 ± 0.2 logMAR) and 20/200 (0.94 ± 0.36 logMAR), respectively (<jats:italic toggle="yes">P</jats:italic> = 0.009). Reading ability recovered in 43% of cases. Microperimetry showed central fixation. A gain of at least 15 letters was obtained in 40% of eyes. Integrity (<jats:italic toggle="yes">P</jats:italic> = 0.009) of external limiting membrane and higher preoperative BCVA (<jats:italic toggle="yes">P</jats:italic> = 0.001) predicted better final BCVA. Complications were retinal detachment (11.4%), macular atrophy (7%), subretinal hemorrhage (4.5%), epiretinal membrane (4.5%), recurrent choroidal neovascular membrane (4.5%), macular hole (3.4%), and cystoid edema (3%).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>Autologous RPE–choroid patch achieved long-lasting BCVA improvement and central fixation, in eyes with choroidal neovascular membrane and intact external limiting membrane. Atrophic maculopathies only obtained temporary visual benefit.</jats:p> </jats:sec>