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Fluit, Ad C.; Rentenaar, Rob J.; Ekkelenkamp, Miquel B.; Severs, Tim T.; Mavinkurve-Groothuis, Annelies M. C.; Rogers, Malbert R. C.; Bruin, Marrie C. A.; Wolfs, Tom F. W.

Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the OprD Outer Membrane Porin

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  • Media type: E-Article
  • Title: Fatal Carbapenem Resistance Development in Pseudomonas Aeruginosa Under Meropenem Monotherapy, Caused by Mutations in the OprD Outer Membrane Porin
  • Contributor: Fluit, Ad C.; Rentenaar, Rob J.; Ekkelenkamp, Miquel B.; Severs, Tim T.; Mavinkurve-Groothuis, Annelies M. C.; Rogers, Malbert R. C.; Bruin, Marrie C. A.; Wolfs, Tom F. W.
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2019
  • Published in: Pediatric Infectious Disease Journal
  • Language: English
  • DOI: 10.1097/inf.0000000000002244
  • ISSN: 0891-3668
  • Keywords: Infectious Diseases ; Microbiology (medical) ; Pediatrics, Perinatology and Child Health
  • Origination:
  • Footnote:
  • Description: <jats:p>A 13-year old neutropenic boy succumbed to bacteremia and sepsis with a <jats:italic toggle="yes">Pseudomonas aeruginosa</jats:italic> strain that rapidly developed resistance to carbapenems during meropenem monotherapy. Whole genome sequencing of the susceptible and resistant blood culture isolates revealed the meropenem-resistant phenotype to be caused by truncation of the <jats:italic toggle="yes">OprD</jats:italic> gene, which added to a preexisting inactivated <jats:italic toggle="yes">mexR</jats:italic> gene.</jats:p>