COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children : A Multinational Study

Media type: E-Article
Title: COVID-19 and Multisystem Inflammatory Syndrome in Latin American Children : A Multinational Study : A Multinational Study
Contributor: Antúnez-Montes, Omar Yassef; Escamilla, Maria Isabel; Figueroa-Uribe, Augusto Flavio; Arteaga-Menchaca, Erick; Lavariega-Saráchaga, Manuel; Salcedo-Lozada, Perla; Melchior, Priscilla; de Oliveira, Rodrigo Beréa; Tirado Caballero, Juan Carlos; Redondo, Hernando Pinzon; Montes Fontalvo, Laura Vanessa; Hernandez, Roger; Chavez, Carolina; Campos, Francisco; Uribe, Fadia; del Aguila, Olguita; Rios Aida, Jorge Alberto; Buitrago, Andrea Parra; Betancur Londoño, Lina Maria; Mendoza Vega, León Felipe; Hernández, Carolina Almeida; Sali, Michela; Higuita Palacio, Julian Esteban; Gomez-Vargas, Jessica; [...]
imprint: Ovid Technologies (Wolters Kluwer Health), 2021
Published in: Pediatric Infectious Disease Journal
Language: English
DOI: 10.1097/inf.0000000000002949
ISSN: 0891-3668
Keywords: Infectious Diseases ; Microbiology (medical) ; Pediatrics, Perinatology and Child Health
Origination:
Footnote:
Description: <jats:sec> <jats:title>Background:</jats:title> <jats:p>To date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, to appropriately plan and allocate resources to face the pandemic on a local and international level.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Ambispective multicenter cohort study from 5 Latin American countries. Children 18 years of age or younger with microbiologically confirmed SARS-CoV-2 infection or fulfilling MIS-C definition were included.</jats:p> </jats:sec> <jats:sec> <jats:title>Findings:</jats:title> <jats:p>Four hundred nine children were included, with a median age of 3.0 years (interquartile range 0.6–9.0). Of these, 95 (23.2%) were diagnosed with MIS-C. One hundred ninety-one (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a pediatric intensive care unit. Ninety-two (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure and 29 (7%) on mechanical ventilation. Thirty-five (8.5%) patients required inotropic support. The following factors were associated with pediatric intensive care unit admission: preexisting medical condition (<jats:italic toggle="yes">P</jats:italic> < 0.0001), immunodeficiency (<jats:italic toggle="yes">P</jats:italic> = 0.01), lower respiratory tract infection (<jats:italic toggle="yes">P</jats:italic> < 0.0001), gastrointestinal symptoms (<jats:italic toggle="yes">P</jats:italic> = 0.006), radiologic changes suggestive of pneumonia and acute respiratory distress syndrome (<jats:italic toggle="yes">P</jats:italic> < 0.0001) and low socioeconomic conditions (<jats:italic toggle="yes">P</jats:italic> = 0.009).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>This study shows a generally more severe form of COVID-19 and a high number of MIS-C in Latin American children, compared with studies from China, Europe and North America, and support current evidence of a more severe disease in Latin/Hispanic children or in people of lower socioeconomic level. The findings highlight an urgent need for more data on COVID-19 in Latin America.</jats:p> </jats:sec>

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