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Oren, Daniel; Moeller, Cathrine M.; Haythe, Jennifer H.; Rubinstein, Gal; Fernandez Valledor, Andrea; Lotan, Dor; Rosenblum, Hannah; Colombo, Paolo C.; Yuzefpolskaya, Melana; Topkara, Veli K.; Clerkin, Kevin J.; Raikhelkar, Jayant K.; Fried, Justin A.; Naka, Yoshifumi; Takeda, Koji; Latif, Farhana; Sayer, Gabriel; Uriel, Nir

Pumping for Two: Pregnancy in Patients Supported With a Left Ventricular Assist Device

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  • Media type: E-Article
  • Title: Pumping for Two: Pregnancy in Patients Supported With a Left Ventricular Assist Device
  • Contributor: Oren, Daniel; Moeller, Cathrine M.; Haythe, Jennifer H.; Rubinstein, Gal; Fernandez Valledor, Andrea; Lotan, Dor; Rosenblum, Hannah; Colombo, Paolo C.; Yuzefpolskaya, Melana; Topkara, Veli K.; Clerkin, Kevin J.; Raikhelkar, Jayant K.; Fried, Justin A.; Naka, Yoshifumi; Takeda, Koji; Latif, Farhana; Sayer, Gabriel; Uriel, Nir
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2023
  • Published in: ASAIO Journal
  • Language: English
  • DOI: 10.1097/mat.0000000000002082
  • ISSN: 1058-2916
  • Keywords: Biomedical Engineering ; General Medicine ; Biomaterials ; Bioengineering ; Biophysics
  • Origination:
  • Footnote:
  • Description: <jats:p>This review discusses the challenges and outcomes associated with pregnancy during left ventricular assist device (LVAD) support. Women account for a third of the heart failure population in the United States. Left ventricular assist devices have emerged as a safe and effective treatment option for patients with advanced heart failure. Pregnancy during LVAD support can occur, and it presents significant risks to both mother and fetus, including hemodynamic stress, thrombotic events, medication-associated teratogenicity, and uterine impingement. This literature review identified 10 cases of confirmed pregnancy during LVAD support, of which eight resulted in successful births. Maternal and fetal mortality occurred in one case, and there was a spontaneous abortion in one case. The review highlights the importance of a multidisciplinary approach, promotion of shared decision-making, thoughtful anticoagulation, adjustment of LVAD speed, and medication optimization to maintain hemodynamic support during pregnancy. Hemodynamic changes during pregnancy include increased cardiac output, heart rate, and plasma volume, as well as decreased systemic vascular resistance, which can impact LVAD support. Despite reduced pulsatility in LVAD-supported patients, ovulation and reproductive capacity might be preserved, and viable pregnancies may be achieved with appropriate management. The review provides insights into the risks and considerations for a viable pregnancy during LVAD support, including the need for ongoing research to inform joined decision-making.</jats:p>