Description:
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<jats:title>Objectives</jats:title>
<jats:p>Few studies have reported on the incidence and risk factors for pouchitis following colectomy and ileal pouch–anal anastomosis (IPAA) in patients with pediatric-onset ulcerative colitis (UC). We aimed to determine clinical predictors for the development of pouchitis following IPAA in this population.</jats:p>
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<jats:title>Patients and methods</jats:title>
<jats:p>We performed a retrospective chart review of all pediatric UC cases that were diagnosed at the Schneider Children’s Medical Center of Israel between 1981 and 2013 and who underwent colectomy during disease course. Potential predictors for pouchitis and chronic pouchitis including various demographic, clinical, endoscopic, and histological variables at diagnosis and at the time of surgery were assessed.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>Of 188 patients with pediatric-onset UC, 33 (18%) underwent colectomy and IPAA surgery. During a median postsurgical follow-up of 7.6 (range: 1–21.5) years following IPAA, 20/33 (60%) patients developed pouchitis including 11/33 (33%) patients who developed chronic pouchitis. Kaplan–Meier survival estimates of the cumulative probability for pouchitis were 9% at 1 year and 36 and 55% at 5 and 10 years, respectively. Multivariate Cox models showed that older age at colectomy (hazard ratio: 0.86, <jats:italic toggle="yes">P</jats:italic>=0.024) was a protective factor, whereas preoperative vitamin-D deficiency (≤20 ng/ml) (hazard ratio: 4.4, <jats:italic toggle="yes">P</jats:italic>=0.021) increased the risk for pouchitis. Age at diagnosis, sex, disease extent, and preoperative therapeutic regimens did not affect the risk of pouchitis.</jats:p>
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<jats:title>Conclusion</jats:title>
<jats:p>Long-term risk for pouchitis is significantly high in pediatric-onset UC after IPAA. Vitamin-D deficiency and younger age at colectomy may increase the risk for pouchitis.</jats:p>
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