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Enikeev, Dmitry; Taratkin, Mark; Efetov, Sergey; Shlomina, Alexandra; Boldyreva, Margarita; Galkina, Irina; Spivak, Leonid; Gitel, Evgeniy; Kuchieva, Agunda; Mikhailov, Vasiliy; Teoh, Jeremy Yuen-Chun; Herrmann, Thomas R.W.; Kikic, Željko; Fomin, Viktor; Shariat, Shahrokh F.; Glybochko, Petr

Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19

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  • Media type: E-Article
  • Title: Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19
  • Contributor: Enikeev, Dmitry; Taratkin, Mark; Efetov, Sergey; Shlomina, Alexandra; Boldyreva, Margarita; Galkina, Irina; Spivak, Leonid; Gitel, Evgeniy; Kuchieva, Agunda; Mikhailov, Vasiliy; Teoh, Jeremy Yuen-Chun; Herrmann, Thomas R.W.; Kikic, Željko; Fomin, Viktor; Shariat, Shahrokh F.; Glybochko, Petr
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2021
  • Published in: Current Opinion in Urology
  • Language: English
  • DOI: 10.1097/mou.0000000000000901
  • ISSN: 0963-0643; 1473-6586
  • Keywords: Urology
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Purpose of review</jats:title> <jats:p>To investigate the possible effects of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) on kidney function and assess the rate of viral ribonucleic acid (RNA) shedding/detection in urine.</jats:p> </jats:sec> <jats:sec> <jats:title>Recent findings</jats:title> <jats:p>Most of the research on the topic suggests that for the moment our ability to estimate whether SARS-CoV-2 is a direct causative agent in acute kidney injury (AKI) or whether it has a cytokine storm effect is limited. During our prospective assessment of 333 patients with COronaVIrus Disease 2019 (COVID-19) it was found that frequency of AKI of 9.6% (32 cases). Despite previous data suggestive of the ability to detect SARS-CoV-2 in urine, we were unable to identify any traces of messenger ribonucleic acid (mRNA) in our group. Both COVID-19 severity (odds ratio, OR = 23.09, confidence interval, CI 7.89–67.57, <jats:italic toggle="yes">P</jats:italic> &lt; 0.001) and chronic kidney disease (CKD) history (OR = 7.17, CI 2.09–24.47, <jats:italic toggle="yes">P</jats:italic> = 0.002) were associated with the AKI rate.</jats:p> </jats:sec> <jats:sec> <jats:title>Summary</jats:title> <jats:p>AKI is a relatively frequent condition for patients with COVID-19 and is normally correlated with the severity of the disease and the patient's history of CKD. The available data fail to address whether SARS-CoV-2 mRNA is present in urine, whereas our prospective trial data suggest that mRNA is undetectable in urine irrespective of the severity of the disease.</jats:p> </jats:sec>