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Oliva, Salvatore; Dias, Jorge Amil; Rea, Francesca; Malamisura, Monica; Espinheira, Maria Céu; Papadopoulou, Alexandra; Koutri, Eleni; Rossetti, Danilo; Orel, Rok; Homan, Matjaž; Bauraind, Olivia; Auth, Marcus Karl-Heinz; Junquera, Carolina Gutierrez; Vande Velde, Saskia; Kori, Michal; Huysentruyt, Koen; Urbonas, Vaidotas; Roma, Eleftheria; Fernández, Sonia Fernández; Domínguez-Ortega, Gloria; Zifman, Eyal; Kafritsa, Panayota; Miele, Erasmo; Zevit, Noam

Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN

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  • Media type: E-Article
  • Title: Characterization of Eosinophilic Esophagitis From the European Pediatric Eosinophilic Esophagitis Registry (pEEr) of ESPGHAN
  • Contributor: Oliva, Salvatore; Dias, Jorge Amil; Rea, Francesca; Malamisura, Monica; Espinheira, Maria Céu; Papadopoulou, Alexandra; Koutri, Eleni; Rossetti, Danilo; Orel, Rok; Homan, Matjaž; Bauraind, Olivia; Auth, Marcus Karl-Heinz; Junquera, Carolina Gutierrez; Vande Velde, Saskia; Kori, Michal; Huysentruyt, Koen; Urbonas, Vaidotas; Roma, Eleftheria; Fernández, Sonia Fernández; Domínguez-Ortega, Gloria; Zifman, Eyal; Kafritsa, Panayota; Miele, Erasmo; Zevit, Noam
  • imprint: Wiley, 2022
  • Published in: Journal of Pediatric Gastroenterology & Nutrition
  • Language: English
  • DOI: 10.1097/mpg.0000000000003530
  • ISSN: 0277-2116
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Objectives:</jats:title> <jats:p>Few pediatric data on phenotypic aspects of eosinophilic esophagitis (EoE) are available. The pEEr registry was developed to prospectively characterize children with EoE from Europe and Israel.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>pEEr is an ongoing prospective registry enrolling children with esophageal eosinophilia (≥15 eos/HPF). Anonymized data were collected from 19 pediatric centers. Data regarding demographics, clinical manifestations, endoscopy, histology, and therapies were collected.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>A total of 582 subjects (61% male) were analyzed. The median age at diagnosis was 10.5 years [interquartile range (IQR): 5.7–17.7], whereas the age at symptom onset was 9.2 years (IQR: 4.3–16.4), resulting in a median diagnostic delay of 1.2 years (IQR: 0.7–2.3). The diagnostic delay was longer below age &lt;6 years. Shorter diagnostic delays were associated with the presence of food allergy or a family history for EoE. Symptoms varied by age with dysphagia and food impaction more common in adolescents, while vomiting and failure to thrive more common in younger children (<jats:italic toggle="yes">P</jats:italic> &lt; 0.001). Among endoscopic findings, esophageal rings were more common in adolescents, whereas exudates were more frequent in younger children(<jats:italic toggle="yes">P</jats:italic> &lt; 0.001). Patients who responded to proton pump inhibitors (PPIs) were more likely to be older, males, and less often presented severe endoscopic findings. Patients unresponsive to PPIs received topical steroids (40%), elimination diet (41%), or a combined therapy (19%).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>EoE findings vary according to age in pediatric EoE. Young children are commonly characterized by non-specific symptoms, atopic dermatitis, food allergy, and inflammatory endoscopic lesions. Adolescents usually have dysphagia or food impaction, fibrostenotic lesions, and a better PPI response.</jats:p> </jats:sec>
  • Access State: Open Access