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Olson, Alex; Ragan, Elizabeth J.; Nakiyingi, Lydia; Lin, Nina; Jacobson, Karen R.; Ellner, Jerrold J.; Manabe, Yukari C.; Sagar, Manish

Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans

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  • Media type: E-Article
  • Title: Brief Report: Pulmonary Tuberculosis Is Associated With Persistent Systemic Inflammation and Decreased HIV-1 Reservoir Markers in Coinfected Ugandans
  • Contributor: Olson, Alex; Ragan, Elizabeth J.; Nakiyingi, Lydia; Lin, Nina; Jacobson, Karen R.; Ellner, Jerrold J.; Manabe, Yukari C.; Sagar, Manish
  • imprint: Ovid Technologies (Wolters Kluwer Health), 2018
  • Published in: JAIDS Journal of Acquired Immune Deficiency Syndromes
  • Language: English
  • DOI: 10.1097/qai.0000000000001823
  • ISSN: 1525-4135
  • Keywords: Pharmacology (medical) ; Infectious Diseases
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Background:</jats:title> <jats:p> <jats:italic toggle="yes">Mycobacterium tuberculosis</jats:italic> (TB) infection induces systemic inflammation that could impact HIV-1 persistence.</jats:p> </jats:sec> <jats:sec> <jats:title>Setting:</jats:title> <jats:p>HIV-1–seropositive individuals either with or without pulmonary TB disease were recruited in Kampala, Uganda.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Plasma cytokines, HIV-1 DNA, and cell-associated (ca)-RNA were compared among those coinfected with TB (cases) to those without TB (controls). TB-coinfected cases and controls were compared at presentation (n = 15 and n = 16, respectively) and at around 6 months after HIV-1 treatment initiation among those who had achieved virologic suppression (n = 6 and n = 8, respectively). At follow-up, the TB-coinfected cases had also finished TB treatment.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Before treatment, the TB-coinfected cases as compared to the controls had higher levels of soluble(s)-CD163 (<jats:italic toggle="yes">P</jats:italic> = 0.0002) and interleukin-6 (<jats:italic toggle="yes">P</jats:italic> = 0.006) but lower levels of macrophage chemoattractant protein-1 (<jats:italic toggle="yes">P</jats:italic> = 0.04). After treatment, the TB-coinfected cases as compared to controls still had higher plasma s-CD163 levels (<jats:italic toggle="yes">P</jats:italic> = 0007). Controls as compared to the coinfected cases had higher ca-RNA per DNA template both at baseline (<jats:italic toggle="yes">P</jats:italic> = 0.03) and at follow-up (<jats:italic toggle="yes">P</jats:italic> = 0.07). Levels of ca-RNA per DNA copy at follow-up showed a negative correlation with baseline plasma s-CD163 (<jats:italic toggle="yes">P</jats:italic> = 0.008) and interleukin-6 (<jats:italic toggle="yes">P</jats:italic> = 0.05) levels.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>TB disease is associated with inflammation and decreased HIV-1 RNA expression relative to the number of infected cells, both before and after viral suppression. Infections present before antiretroviral initiation impact HIV-1 latency.</jats:p> </jats:sec>
  • Access State: Open Access