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Sattari, Shahab Aldin; Sattari, Ali Reza; Makary, Martin A.; Hu, Chen; He, Jin

Laparoscopic Versus Open Pancreatoduodenectomy in Patients With Periampullary Tumors : A Systematic Review and Meta-analysis

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  • Media type: E-Article
  • Title: Laparoscopic Versus Open Pancreatoduodenectomy in Patients With Periampullary Tumors : A Systematic Review and Meta-analysis : A Systematic Review and Meta-analysis
  • Contributor: Sattari, Shahab Aldin; Sattari, Ali Reza; Makary, Martin A.; Hu, Chen; He, Jin
  • Published: Ovid Technologies (Wolters Kluwer Health), 2023
  • Published in: Annals of Surgery, 277 (2023) 5, Seite 742-755
  • Language: English
  • DOI: 10.1097/sla.0000000000005785
  • ISSN: 0003-4932
  • Origination:
  • Footnote:
  • Description: <jats:sec> <jats:title>Objective:</jats:title> <jats:p>To conduct a systematic review and meta-analysis of randomized controlled trials compared laparoscopic pancreatoduodenectomy (LPD) versus open pancreatoduodenectomy (OPD) in patients with periampullary tumors.</jats:p> </jats:sec> <jats:sec> <jats:title>Background:</jats:title> <jats:p>LPD has gained attention; however, its safety and efficacy versus OPD remain debatable.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>We searched PubMed and Embase. Primary outcomes were the length of hospital stay (LOS) (day), Clavien-Dindo grade ≥III complications, and 90-day mortality. Secondary outcomes were blood loss (milliliter), blood transfusion, duration of operation (minute), readmission, reoperation, comprehensive complication index score, bile leak, gastrojejunostomy or duodenojejunostomy leak, postoperative pancreatic fistula, postpancreatectomy hemorrhage, delayed gastric emptying, surgical site infection, intra-abdominal infection, number of harvested lymph nodes, and R0 resection. Pooled odds ratio (OR) or mean difference (MD) of data was calculated using the random-effect model. The grading of recommendations, assessment, development and evaluation approach was used for grading the level of evidence.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Four randomized controlled trials yielding 818 patients were included, of which 411 and 407 patients underwent LPD and OPD, respectively. The meta-analysis concluded that 2 approaches were similar, except in the LPD group, the LOS tended to be shorter [MD=−2.54 (−5.17, 0.09), <jats:italic toggle="yes">P</jats:italic>=0.06], LOS in ICU was shorter [MD=−1 (−1.8, −0.2), <jats:italic toggle="yes">P</jats:italic>=0.01], duration of operation was longer [MD=75.16 (23.29, 127.03), <jats:italic toggle="yes">P</jats:italic>=0.005], blood loss was lower [MD=−115.40 (−152.13, −78.68), <jats:italic toggle="yes">P</jats:italic>&lt;0.00001], blood transfusion was lower [OR=0.66 (0.47, 0.92), <jats:italic toggle="yes">P</jats:italic>=0.01], and surgical site infection was lower [OR=0.35 (0.12, 0.96), <jats:italic toggle="yes">P</jats:italic>=0.04]. The overall certainty of the evidence was moderate.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions:</jats:title> <jats:p>Within the hands of highly skilled surgeons in high-volume centers, LPD is feasible and as safe and efficient as OPD.</jats:p> </jats:sec>