• Media type: E-Article
  • Title: A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride
  • Contributor: Jia, Mingzhu; Jiang, Lixue; Niu, Fanfan; Zhang, Yu; Sun, Xiaoling
  • Published: The Royal Society, 2018
  • Published in: Royal Society Open Science, 5 (2018) 2, Seite 171988
  • Language: English
  • DOI: 10.1098/rsos.171988
  • ISSN: 2054-5703
  • Keywords: Multidisciplinary
  • Origination:
  • Footnote:
  • Description: Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl) 2 ) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl) 2 system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of 31 P NMR spectroscopy.
  • Access State: Open Access