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Media type:
E-Article
Title:
Mixed patterns of transmission of human herpesvirus-8 (Kaposi’s sarcoma-associated herpesvirus) in Malawian families
Contributor:
Cook, Rachelle D.;
Hodgson, Tim A.;
Waugh, Alastair C. W.;
Molyneux, Elizabeth M.;
Borgstein, Eric;
Sherry, A.;
Teo, Chong Gee;
Porter, Stephen R.
Published:
Microbiology Society, 2002
Published in:
Journal of General Virology, 83 (2002) 7, Seite 1613-1619
Language:
English
DOI:
10.1099/0022-1317-83-7-1613
ISSN:
0022-1317;
1465-2099
Origination:
Footnote:
Description:
To study transmission patterns of human herpesvirus-8 (HHV-8) (Kaposi’s sarcoma-associated herpesvirus) in families in Malawi, nucleotide sequences derived from two hypervariable loci of the HHV-8 genome, the V1 and V2 regions of open reading frame K1 (K1/V1 and K1/V2, respectively), were amplified from blood and mouth rinse samples of 22 patients with treated and untreated Kaposi’s sarcoma (KS) and their first-degree relatives (n=67). In patients with KS, vincristine therapy was significantly associated with non-detectability of circulating, but not oral, K1/V1 DNA. Intra-familial K1/V1 phylogenetic comparisons of eight families were possible. Both identical and non-identical sequences were observed between family members, suggesting transmission of HHV-8 along both intra- and extra-familial transmission routes.