You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Novel divergent nidovirus in a python with pneumonia
Contributor:
Bodewes, Rogier;
Lempp, Charlotte;
Schürch, Anita C.;
Habierski, Andre;
Hahn, Kerstin;
Lamers, Mart;
von Dörnberg, Katja;
Wohlsein, Peter;
Drexler, Jan Felix;
Haagmans, Bart L.;
Smits, Saskia L.;
Baumgärtner, Wolfgang;
Osterhaus, Albert D. M. E.
Published:
Microbiology Society, 2014
Published in:
Journal of General Virology, 95 (2014) 11, Seite 2480-2485
Language:
English
DOI:
10.1099/vir.0.068700-0
ISSN:
0022-1317;
1465-2099
Origination:
Footnote:
Description:
The order Nidovirales contains large, enveloped viruses with a non-segmented positive-stranded RNA genome. Nidoviruses have been detected in man and various animal species, but, to date, there have been no reports of nidovirus in reptiles. In the present study, we describe the detection, characterization, phylogenetic analyses and disease association of a novel divergent nidovirus in the lung of an Indian python (Python molurus) with necrotizing pneumonia. Characterization of the partial genome (>33 000 nt) of this virus revealed several genetic features that are distinct from other nidoviruses, including a very large polyprotein 1a, a putative ribosomal frameshift signal that was identical to the frameshift signal of astroviruses and retroviruses and an accessory ORF that showed some similarity with the haemagglutinin–neuraminidase of paramyxoviruses. Analysis of genome organization and phylogenetic analysis of polyprotein 1ab suggests that this virus belongs to the subfamily Torovirinae. Results of this study provide novel insights into the genetic diversity within the order Nidovirales.