Comparative Effectiveness of Intracranial Pressure Monitoring on 6-Month Outcomes of Critically Ill Patients With Traumatic Brain Injury

Media type: E-Article
Title: Comparative Effectiveness of Intracranial Pressure Monitoring on 6-Month Outcomes of Critically Ill Patients With Traumatic Brain Injury
Contributor: Nattino, Giovanni; Gamberini, Lorenzo; Brissy, Obou; Carrara, Greta; Chesnut, Randall; Chiarini, Valentina; Chieregato, Arturo; Csomos, Akos; Fleming, Joanne M.; Gradisek, Primoz; Kaps, Rafael; Kyprianou, Theodoros; Lazar, Isaac; Lemeshow, Stanley; Mikaszewska-Sokolewicz, Malgorzata; Paci, Giulia; Rossi, Carlotta; Temkin, Nancy; Xirouchaki, Nektaria; Giugni, Aimone; Bertolini, Guido; Agostini, Fulvio; Ajmone-Cat, Claudio; Bassi, Giovanni; [...]
imprint: American Medical Association (AMA), 2023
Published in: JAMA Network Open
Language: English
DOI: 10.1001/jamanetworkopen.2023.34214
ISSN: 2574-3805
Origination:
Footnote:
Description: <jats:sec id="ab-zoi230986-4"><jats:title>Importance</jats:title><jats:p>While the relationship between persistent elevations in intracranial pressure (ICP) and poorer outcomes is well established for patients with traumatic brain injury (TBI), there is no consensus on how ICP measurements should drive treatment choices, and the effectiveness of ICP monitoring remains unknown.</jats:p></jats:sec><jats:sec id="ab-zoi230986-5"><jats:title>Objective</jats:title><jats:p>To evaluate the effectiveness of ICP monitoring on short- and mid-term outcomes of patients with TBI.</jats:p></jats:sec><jats:sec id="ab-zoi230986-6"><jats:title>Design, Setting, and Participants</jats:title><jats:p>CREACTIVE was a prospective cohort study that started in March 2014 and lasted 5 years. More than 8000 patients with TBI were enrolled at 83 intensive care units (ICUs) from 7 countries who joined the CREACTIVE Consortium. Patients with TBI who met the Brain Trauma Foundation guidelines for ICP monitoring were selected for the current analyses, which were performed from January to November 2022.</jats:p></jats:sec><jats:sec id="ab-zoi230986-7"><jats:title>Exposure</jats:title><jats:p>Patients who underwent ICP monitoring within 2 days of injury (exposure group) were propensity score–matched to patients who were not monitored or who underwent monitoring 2 days after the injury (control group).</jats:p></jats:sec><jats:sec id="ab-zoi230986-8"><jats:title>Main Outcome and Measure</jats:title><jats:p>Functional disability at 6 months as indicated by Glasgow Outcome Scale–Extended (GOS-E) score.</jats:p></jats:sec><jats:sec id="ab-zoi230986-9"><jats:title>Results</jats:title><jats:p>A total of 1448 patients from 43 ICUs in Italy and Hungary were eligible for analysis. Of the patients satisfying the ICP-monitoring guidelines, 503 (34.7%) underwent ICP monitoring (median [IQR] age: 45 years [29-61 years]; 392 males [77.9%], 111 females [22.1%]) and 945 were not monitored (median [IQR] age: 66 years [48-78 years]; 656 males [69.4%], 289 females [30.6%]). After matching to balance the variables, worse 6-month recovery was observed for monitored patients compared with nonmonitored patients (death/vegetative state: 39.2% vs 40.6%; severe disability: 33.2% vs 25.4%; moderate disability: 15.7% vs 14.9%; good recovery: 11.9% vs 19.1%, respectively; <jats:italic>P</jats:italic> = .005). Monitored patients received medical therapies significantly more frequently.</jats:p></jats:sec><jats:sec id="ab-zoi230986-10"><jats:title>Conclusions and Relevance</jats:title><jats:p>In this cohort study, ICP monitoring was associated with poorer recovery and more frequent medical interventions with their relevant adverse effects. Optimizing the value of ICP monitoring for TBI requires further investigation on monitoring indications, clinical interventions, and management protocols.</jats:p></jats:sec>
Access State: Open Access

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