Description:
<jats:p>The platelet‐derived growth factor receptors alpha and beta (<jats:styled-content style="fixed-case">PDGFR</jats:styled-content>α and <jats:styled-content style="fixed-case">PDGFR</jats:styled-content>β) mark fibroadipogenic progenitor cells/fibroblasts and pericytes in skeletal muscle, respectively. While the role that these cells play in muscle growth and development has been evaluated, it was not known whether the <jats:styled-content style="fixed-case">PDGF</jats:styled-content> receptors activate signaling pathways that control transcriptional and functional changes during skeletal muscle hypertrophy. To evaluate this, we inhibited <jats:styled-content style="fixed-case">PDGFR</jats:styled-content> signaling in mice subjected to a synergist ablation muscle growth procedure, and performed analyses 3 and 10 days after induction of hypertrophy. The results from this study indicate that <jats:styled-content style="fixed-case">PDGF</jats:styled-content> signaling is required for fiber hypertrophy, extracellular matrix production, and angiogenesis that occur during muscle growth.</jats:p>