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Steiner‐Lim, Genevieve Z.; Bensoussan, Alan; Andrews‐Marney, Elana R.; Al‐Dabbas, Mahmoud A.; Cave, Adele E.; Chiu, Christine L.; Christofides, Katerina; De Blasio, Frances M.; Dewsbury, Lauren S.; Fagan, Naomi L.; Fogarty, Jack S.; Hattom, Lena C.; Hohenberg, Mark I.; Jafar, Deyyan; Karamacoska, Diana; Lim, Chai K.; Liu, Jianxun; Metri, Najwa‐Joelle; Oxenham, D. Vincent; Ratajec, Holly; Roy, Nikita; Shipton, Danielle G.; Varjabedian, David; Chang, Dennis H.

A randomized, double‐blind, placebo‐controlled, parallel‐group 12‐week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment

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  • Media type: E-Article
  • Title: A randomized, double‐blind, placebo‐controlled, parallel‐group 12‐week pilot phase II trial of SaiLuoTong (SLT) for cognitive function in older adults with mild cognitive impairment
  • Contributor: Steiner‐Lim, Genevieve Z.; Bensoussan, Alan; Andrews‐Marney, Elana R.; Al‐Dabbas, Mahmoud A.; Cave, Adele E.; Chiu, Christine L.; Christofides, Katerina; De Blasio, Frances M.; Dewsbury, Lauren S.; Fagan, Naomi L.; Fogarty, Jack S.; Hattom, Lena C.; Hohenberg, Mark I.; Jafar, Deyyan; Karamacoska, Diana; Lim, Chai K.; Liu, Jianxun; Metri, Najwa‐Joelle; Oxenham, D. Vincent; Ratajec, Holly; Roy, Nikita; Shipton, Danielle G.; Varjabedian, David; Chang, Dennis H.
  • Published: Wiley, 2023
  • Published in: Alzheimer's & Dementia: Translational Research & Clinical Interventions, 9 (2023) 4
  • Language: English
  • DOI: 10.1002/trc2.12420
  • ISSN: 2352-8737
  • Keywords: Psychiatry and Mental health ; Neurology (clinical)
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:sec><jats:title>INTRODUCTION</jats:title><jats:p>This study primarily aimed to evaluate the efficacy and safety of SaiLuoTong (SLT) on cognition in mild cognitive impairment (MCI).</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>Community‐dwelling people with MCI aged ≥60 years were randomly assigned to 180 mg/day SLT or placebo for 12 weeks.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Thirty‐nine participants were randomized to each group (<jats:italic>N</jats:italic> = 78); 65 were included in the final analysis. After 12 weeks, the between‐groups difference in Logical Memory delayed recall scores was 1.40 (95% confidence interval [CI]: 0.22 to 2.58; <jats:italic>P</jats:italic> = 0.010); Delis–Kaplan Executive Function System Trail Making Test Condition 4 switching and contrast scaled scores were 1.42 (95% CI: –0.15 to 2.99; <jats:italic>P</jats:italic> = 0.038) and 1.56 (95% CI: –0.09 to 3.20; <jats:italic>P</jats:italic> = 0.032), respectively; Rey Auditory Verbal Learning Test delayed recall was 1.37 (95% CI: –0.10 to 2.84; <jats:italic>P</jats:italic> = 0.034); and Functional Activities Questionnaire was 1.21 (95% CI: –0.21 to 2.63; <jats:italic>P</jats:italic> = 0.047; <jats:italic>P</jats:italic> &lt; 0.001 after controlling for baseline scores).</jats:p></jats:sec><jats:sec><jats:title>DISCUSSION</jats:title><jats:p>SLT is well tolerated and may be useful in supporting aspects of memory retrieval and executive function in people with MCI.</jats:p></jats:sec><jats:sec><jats:title>Highlights</jats:title><jats:p><jats:list list-type="bullet"> <jats:list-item><jats:p>SaiLuoTong (SLT) improves delayed memory retrieval and executive function in people with mild cognitive impairment (MCI).</jats:p></jats:list-item> <jats:list-item><jats:p>SLT is well tolerated in people ≥ 60 years.</jats:p></jats:list-item> <jats:list-item><jats:p>The sample of community dwellers with MCI was well characterized and homogeneous.</jats:p></jats:list-item> </jats:list></jats:p></jats:sec>
  • Access State: Open Access