You can manage bookmarks using lists, please log in to your user account for this.
Media type:
E-Article
Title:
Antibodies from plants for bionanomaterials
Contributor:
Edgue, Gueven;
Twyman, Richard M;
Beiss, Veronique;
Fischer, Rainer;
Sack, Markus
imprint:
Wiley, 2017
Published in:WIREs Nanomedicine and Nanobiotechnology
Language:
English
DOI:
10.1002/wnan.1462
ISSN:
1939-0041;
1939-5116
Origination:
Footnote:
Description:
<jats:p>Antibodies are produced as part of the vertebrate adaptive immune response and are not naturally made by plants. However, antibody <jats:styled-content style="fixed-case">DNA</jats:styled-content> sequences can be introduced into plants, and together with laboratory technologies that allow the design of antibodies recognizing any conceivable molecular structure, plants can be used as ‘green factories’ to produce any antibody at all. The advent of plant‐based transient expression systems in particular allows the rapid, convenient, and safe production of antibodies, ranging from laboratory‐scale expression to industrial‐scale manufacturing. The key features of plant‐based production include safety, speed, low cost, and convenience, allowing newcomers to rapidly master the technology and use it to its full advantage. Manufacturing in plants has recently achieved significant milestones and offers more than just an alternative to established microbial and mammalian cell platforms. The use of plants for product development in particular offers the power and flexibility to easily coexpress many different genes, allowing the plug‐and‐play construction of novel bionanomaterials, perfectly complementing existing approaches based on plant virus‐like particles. As well as producing single antibodies for applications in medicine, agriculture, and industry, plants can be used to produce antibody‐based supramolecular structures and scaffolds as a new generation of green bionanomaterials that promise a bright future based on clean and renewable nanotechnology applications. <jats:italic>WIREs Nanomed Nanobiotechnol</jats:italic> 2017, 9:e1462. doi: 10.1002/wnan.1462</jats:p><jats:p>This article is categorized under:
<jats:list list-type="explicit-label">
<jats:list-item><jats:p>Therapeutic Approaches and Drug Discovery > Emerging Technologies</jats:p></jats:list-item>
<jats:list-item><jats:p>Diagnostic Tools > In Vivo Nanodiagnostics and Imaging</jats:p></jats:list-item>
<jats:list-item><jats:p>Biology-Inspired Nanomaterials > Protein and Virus-Based Structures</jats:p></jats:list-item>
</jats:list></jats:p>